3M™ Zeta Plus™ Encapsulated Filter Capsules with ZB Grade Media extend depth filtration capacity and enhances the protection of downstream membranes thereby extending filter life. 3M™ Zeta Plus™ ™ Encapsulated Filter Capsules with ZB Grade Media are part of a family of advanced dual zone depth filters designed to provide optimal clarification of bioprocess, biological and pharmaceutical fluids.
3M™ Zeta Plus™ ™ Encapsulated Filter Capsules with ZB Grade Media contain two distinct layers, or “zones,” of filter media with the upstream zone more open than the downstream zone. This structure enhances the contaminant holding capacity of the filter media since larger particles are trapped in the upper zone of the filter media and smaller particles are trapped in the lower zone. This media structure helps reduce premature plugging and extends service life. The two filter zones can be independently selected and combined to optimize performance.
3M™ Zeta Plus™ Encapsulated Filter Capsules with ZB Grade Media are optimized for clarification of mammalian cell harvest fluids and for protection of downstream sterilizing grade membrane filters. Their strong positive charge provides enhanced reduction of negatively charged contaminants compared to a mechanical filtration mechanism alone. In solution cells, cellular debris, endotoxins, and nucleic acids (DNA, RNA) carry a negative charge. 3M's application of positive zeta potential to ZB filter media creates a filter matrix that enhances the capture of negatively charged contaminants for maximum filtration performance. The strong positive charge over a broad pH range makes these filters ideal for cell broth clarification and for protection of downstream membrane filters
Clarification of mammalian cell culture process fluids (cell separation)
Protection of downstream processes including membrane filters and chromatography columns
Clarification of bacteria and yeast cell lysates
Endotoxin and nucleic acid reduction
Clarification of colloidal and haze forming contaminants
3M™ Zeta Plus™ ™ Encapsulated Filter Capsules with ZB Grade Media are supported with a Regulatory Support File (3M literature 70-0203-0883-2) and Certificate of Quality to ease validation and regulatory submissions. The products are also documented in a Drug Master File (DMF) on record with the US Food and Drug Administration (FDA).
The 3M™ Zeta Plus™ ™ Encapsulated Filter Capsules with ZB Grade Media are available in six grades. Operating conditions and the fluid being filtered impact retention performance. 3M Purification recommends small-scale pilot runs to confirm grade selection prior to full scale-up. 3M Purification's Technical Services staff can assist in grade selection as well as perform onsite evaluations.
A History of Innovation
For more than a century, 3M has applied innovation and technology to improve customers’ lives and support their business goals. From its headquarters in St. Paul, Minnesota, 3M serves industrial and commercial customers and consumers in nearly 200 countries. Across thousands of products, the 3M brand represents consistency, superior quality, and value. The 3M success begins with a culture of creative collaboration that inspires a never-ending stream of powerful technologies and product solutions that make life better. 3M has an ability to apply technologies – often in combination – to an endless array of real-world customer needs. Of course, all of this is made possible by the people of 3M and a singular commitment to make life easier and better for people around the world. Toward that end, 3M is committed to providing innovative, cost-effective products that help protect people, equipment and the environment. 3M Purification Inc. (formerly CUNO Incorporated) provides filtration and separation solutions for residential, foodservice, science labs, industrial, marine and other applications.